HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Rubenstein, R. Articles by Price, R. W. Search for Related Content PubMed PubMed Citation Articles by Rubenstein, R. Articles by Price, R. W. Agricola Articles by Rubenstein, R. Articles by Price, R. W.

Preservation of Catecholamine Uptake and Release in Herpes Simplex Virus Type 1-infected PC12 Cells

Cotzias Laboratory of Neuro-Oncology, Memorial Sloan-Kettering Cancer Center, New York, N.Y. 10021, U.S.A.

The PC12 cell line, which is derived from a rat pheochromocytoma and possesses a number of ‘differentiated’ neuronal properties, was used to characterize the effect of herpes simplex virus type 1 (HSV-1) infection on the uptake and release of catecholamines. Both the uptake of [³H]norepinephrine and the content and K⁺-induced release of endogenous catecholamines were remarkably preserved during the course of productive infection. HSV-1 infection is thus selective in its effects on the host cell and certain specialized functional properties may be retained in the face of otherwise profound metabolic alterations.

Keywords: HSV-1, neurons, catecholamines

Received 20 May 1983; accepted 15 August 1983.