HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Speelman, D. J. Articles by Albrecht, T. Search for Related Content PubMed PubMed Citation Articles by Speelman, D. J. Articles by Albrecht, T. Agricola Articles by Speelman, D. J. Articles by Albrecht, T.

Reduction of 4-Nitroquinoline 1-Oxide to 4-Hydroxyaminoquinoline 1-Oxide in Lysates of Cytomegalovirus-infected Cells

Alison Culling^2,

James S. Kittredge^3,

¹ Department of Microbiology
² Pharmacology and Toxicology
and³ Marine Biomedical Institute, University of Texas Medical Branch, Galveston, Texas 77550, U.S.A.

The rates of virus inactivation by 4-nitroquinoline 1-oxide (NQO) and 4-hydroxyaminoquinoline 1-oxide (HAQO) were compared and samples of cytomegalovirus (CMV)-infected cell lysates to which NQO had been added were examined for the presence of HAQO. These experiments demonstrated that (i) CMV inactivation by HAQO was more rapid than with NQO, (ii) virus inactivation by either NQO or HAQO failed to demonstrate a photodynamic component, and (iii) NQO-treated stocks contained HAQO, indicating reduction of NQO to HAQO. The results support the concept that metabolism of NQO to HAQO enhances the genotoxic effect of NQO.

Keywords: cytomegalovirus, carcinogenesis, NQO, HAQO

Present address: Department of Pharmacology, Arizona Health Sciences Center, Tucson, Arizona 85724, U.S.A.

Present address: University of Southern California, 820 South Seaside Avenue, Fish Harbor, Terminal Island, California 90731, U.S.A.

Received 14 April 1983; accepted 14 July 1983.