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J Gen Virol 64 (1983), 2549-2559; DOI 10.1099/0022-1317-64-12-2549
© 1983 Society for General Microbiology
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Structural Organization of Unique Retrovirus-like Particles Budding from Human Teratocarcinoma Cell Lines

Klaus Boller1, Hermann Frank1, Johannes Löwer2, Roswitha Löwer3 and Reinhard Kurth2

1 Max-Planck-Institut für Virusforschung, 7400 Tübingen
2 Paul-Ehrlich-Institut, 6000 Frankfurt am Main
and3 Friedrich-Miescher-Laboratorium, Max-Planck-Institut, 7400 Tübingen, Federal Republic of Germany

Human teratocarcinoma cells cultured in vitro can be induced to produce retroviruslike particles. The induction procedures are the same as those previously shown to induce the synthesis of animal retroviruses. Electron microscopical evidence is presented that the human teratocarcinoma-derived (HTD) particles are most closely related to the type C retrovirus strains. HTD particles can be banded at 1.16 g/ml in linear sucrose gradients, the characteristic density for retroviruses, and subsequently be used for negative staining and fine structure analysis.

Keywords: retrovirus, induction, EM, teratocarcinoma

Received 21 June 1983; accepted 22 August 1983.


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