HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Hill, T. J. Articles by Harbour, D. A. Search for Related Content PubMed PubMed Citation Articles by Hill, T. J. Articles by Harbour, D. A. Agricola Articles by Hill, T. J. Articles by Harbour, D. A.

Recurrence of Herpes Simplex in the Mouse Requires an Intact Nerve Supply to the Skin

Department of Microbiology, The Medical School, University Walk, Bristol BS8 1TD, U.K.

The nerves supplying the pinna of the ear of mice latently infected in the 2nd and 3rd cervical ganglia were sectioned. Immediately after neurotomy, or some days later, the denervated ears were stripped with cellophane tape to induce recurrent disease. The cervical ganglia and skin of the ears were tested for the presence of infectious virus at different times after neurotomy. Nerve section induced a low incidence of reactivation of virus in ganglia. After neurotomy, infectious virus was isolated from the skin very rarely and recurrent disease was not seen.

Keywords: neurotomy, HSV-1, recurrent disease

Received 20 June 1983; accepted 26 August 1983.