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Mouse Interferon Receptors: A Difference in Their Response to and Interferons

Department of Microbiology, School of Medicine, University of Southern California, Los Angeles, California 90033, U.S.A.

The interferon receptors of C3H/10T mouse cells respond differently to and interferons under certain conditions. If C3H/10T cells which have been maintained in logarithmic growth phase are exposed to trypsin or Pronase immediately before they are treated with mouse interferons, they evince an antiviral response to interferon but not to interferon. In contrast, contact-inhibited C3H/10T cells, L-929 mouse cells or human HEL cells lost the ability to respond to both and interferons after treatment with trypsin or Pronase. When L-929 cells are incubated at 37 °C following exposure to these proteolytic enzymes, they completely regain their ability to respond to mouse interferon within 2 h. These observations suggest that the receptors for and interferons are different in their topographical distribution in C3H/10T cells.

Keywords: IFN receptors, IFN (MuIFN- and ), receptors

Received 3 June 1983; accepted 25 August 1983.

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