HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Ross, L. J. N. Articles by Biggs, P. M. Search for Related Content PubMed PubMed Citation Articles by Ross, L. J. N. Articles by Biggs, P. M. Agricola Articles by Ross, L. J. N. Articles by Biggs, P. M.

Restriction Endonuclease Analysis of Marek's Disease Virus DNA and Homology between Strains

Houghton Poultry Research Station, Houghton, Huntingdon, U.K.

The restriction endonuclease patterns of viral DNA obtained from serotypes 1 and 2 strains of Marek's disease virus have been compared and homology between the strains examined by hybridization. The results have shown that HPRS 16 (serotype 1) DNA has a structure similar to its attenuated variant HPRS 16/att except for a few fragments that are present only in the virulent strain. Evidence was obtained which suggested that these restriction fragments contained repeat sequences and that insertion of heterogeneous DNA occurred at these sites during attenuation of HPRS 16. The restriction enzyme patterns of HPRS 24 (serotype 2) differed substantially from those of HPRS 16 and HPRS 16/att and reassociation experiments showed that HPRS 24 shares less than 10% homology with either HPRS 16 or herpesvirus of turkeys (serotype 3).

Keywords: MDV, restriction enzyme analysis

Received 14 June 1983; accepted 7 September 1983.

This article has been cited by other articles:

				S. Murata, K.-S. Chang, S.-I. Lee, S. Konnai, M. Onuma, and K. Ohashi Development of a nested polymerase chain reaction method to detect oncogenic Marek's disease virus from feather tips J Vet Diagn Invest, September 1, 2007; 19(5): 471 - 478. [Abstract] [Full Text] [PDF]

				K. W. Jarosinski, N. Osterrieder, V. K. Nair, and K. A. Schat Attenuation of Marek's Disease Virus by Deletion of Open Reading Frame RLORF4 but Not RLORF5a J. Virol., September 15, 2005; 79(18): 11647 - 11659. [Abstract] [Full Text] [PDF]

				D. Endoh, K.-O. Cho, K. Tsukamoto, T. Morimura, Y. Kon, and M. Hayashi Application of Representational Difference Analysis to Genomic Fragments of Marek's Disease Virus J. Clin. Microbiol., December 1, 2000; 38(12): 4310 - 4314. [Abstract] [Full Text]