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Bovine Lymphosarcoma: Processing of Bovine Leukaemia Virus-coded Proteins

Institut National de la Santé et de la Recherche Médicale Unité 117, 229 cours de l'Argonne, 33076 Bordeaux Cedex, France

This report describes pulse-chase experiments performed with cells infected with tumour-derived bovine leukaemia virus (BLV) and using purified -globulins directed against BLV structural proteins, namely gp51, p24, p15 and p12. A gpr72 was found to be the precursor of the gp51 with a gpr70 intermediate. The p12 was shown to be derived from a pr40 with numerous intermediates (pr35, pr22, pr16 and pr14). The p24 and p15 originate from a pr42. Both the pr42 and pr40 are derived from a common pr70. A P45, a P52 and a P27 were also detected. Because these three proteins were found to accumulate progressively in cells and because they were not observed to be processed, they might play a physiological role in infected cells.

Keywords: BLV, structural and precursor, proteins

Received 21 February 1983; accepted 22 August 1983.