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Evidence for Several Unrelated Neutralization Epitopes of Poliovirus, Type 1, Strain Mahoney, Provided by Neutralization Tests and Quantitative Enzyme-linked Immunosorbent Assay (ELISA)

Rudolf Dernick

Heinrich-Pette-Institut für Experimentelle Virologie und Immunologie an der Universität Hamburg, Martinistrasse 52, 2000 Hamburg 20, Federal Republic of Germany

With the aid of 11 neutralizing monoclonal antibodies which were investigated in four different neutralization tests, evidence was provided that several unrelated epitopes for neutralizing antibodies exist on the surface of poliovirus type 1. All monoclonal antibodies were able to neutralize poliovirus infectivity prior to and after virus adsorption to host cells. The quantitative enzyme-linked immunosorbent assay is introduced as a second independent system for the determination of antibody specificity. Antibodies could be divided into four groups according to their reaction patterns.

Keywords: poliovirus, neutralization, epitopes, ELISA

R.D. changed his name from Drzeniek to Dernick in 1980.

Received 7 March 1983; accepted 23 August 1983.