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Institut für Medizinische Mikrobiologie und Immunologie der Universität Bonn, 5300 Bonn-Venusberg, Federal Republic of Germany
A cloned culture of secondary anti-herpes simplex virus (anti-HSV) cytotoxic T lymphocytes (CTL) generated in vitro when adoptively transferred to intact or cyclophosphamide (CP) pretreated syngeneic mice protected the recipients from death following intraperitoneal infection with HSV-1. This in vivo protective effect conferred by anti-HSV CTL was virus-specific and H-2K/D-restricted. Twenty-four h after HSV-1 infection of BALB/c mice (intact or CP-pretreated) relatively high levels of serum interferon-
were observed in the recipients of syngeneic anti-HSV CTL and this event may explain, at least in part, the CTL-mediated protective effect.
Keywords: HSV-1, cytotoxic T lymphocytes, protection
Received 21 July 1982;
accepted 28 September 1982.
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