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J Gen Virol 64 (1983), 449-453; DOI 10.1099/0022-1317-64-2-449
© 1983 Society for General Microbiology
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The Epstein-Barr Virus Receptor is Distinct from the C3 Receptor

Alan Wells1,{dagger}, Norio Koide1,{ddagger}, Harald Stein2, Johannes Gerdes2 and George Klein1

1 Institute for Tumor Biology, Karolinska Institute, S-104 01 Stockholm 60, Sweden
2 Department of Pathology, Christian Albrechts University, Kiel, Federal Republic of Germany

Polyvalent serum directed against C3 receptors was employed in an attempt to block Epstein—Barr virus (EBV) binding to virus receptor-containing cell lines. The serum eliminated 90% of virus binding to Daudi and BJAB, lines which express only the C3d receptor. Raji and Ramos cells, which express the C3d, C3b and C3bi receptors, still adsorbed 70% of their virus capacity in the presence of excess antiserum. These effects were independent of the virus strain. In the light of previous reports, these data imply that, although the two receptors, EBV and C3d, are closely associated, the binding sites of EBV and complement are distinct. Additionally, an unusual EBV substrain-specific receptor found on U698 and P3HR-1/ASNP lines was shown to be independent of complement receptors.

Keywords: EBV receptor, C3 receptor, virus binding, complement

{dagger} Present address: Box G, Brown University, Providence, Rhode Island 02912, U.S.A.

{ddagger} Present address: Department of Internal Medicine, Okayama University Medical School, 2-5-1 Shikata-cho, Okayama 700, Japan.

Received 25 June 1982; accepted 27 August 1982.




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Copyright © 1983 by the Society for General Microbiology.