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Responses to Interferon of LM Cells Growing Continuously in the Absence of Serum and Exogenous Lipids

¹ Laboratory de Biologie Moléculaire
et de² Laboratory de Biochimie des Protéines, ERA CNRS 482 Université de Montpellier II, Place E. Bataillon, 34060 Montpellier Cedex
³ Laboratoire de Biochimie A, Faculté de Médecine Bld Henri IV, 34000 Montpellier, France

Mouse fibroblast LM cells growing continuously in the absence of serum and exogenous lipids are proposed as a model for studying interferon action. Several of its activities, namely the inhibition of virus and cell growth, and the increased cytotoxicity of poly(rI)·poly(rC), are shown to be potentiated in such conditions. Since cells cultured under these conditions are devoid of precursors of prostaglandin biosynthesis, the data suggest that none of the three effects of interferon depends on active prostaglandin synthesis.

Keywords: interferon, prostaglandin, serum-free cultures

Received 27 May 1982; accepted 20 September 1982.