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Prostaglandins Enhance Intercellular Adhesion of Vero Cells Infected with Herpes Simplex Virus

Department of Microbiology, The Medical School, Bristol BS8 1TD, U.K.

The effect of prostaglandins (PGs) and cyclic nucleotides on adherence between uninfected Vero cells or between uninfected cells and cells infected with wild-type or syncytial strains of herpes simplex virus (HSV) was studied. In the absence of serum, PGE₂ increased adhesion between uninfected cells whereas PGF₂ decreased it. However, both PGE₂ and PGF₂ increased adhesion between cells infected with HSV and uninfected cells. Moreover, dibutyryl cyclic AMP increased adhesion between uninfected cells and cells infected with HSV, whereas dibutyryl cyclic GMP decreased it.

Keywords: HSV, prostaglandins, adhesion between cells, cyclic nucleotides

Received 23 August 1982; accepted 26 October 1982.