J Gen Virol Try IJSEM Online
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Gen Virol 64 (1983), 693-696; DOI 10.1099/0022-1317-64-3-693
© 1983 Society for General Microbiology
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Coulon, P.
Right arrow Articles by Flamand, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Coulon, P.
Right arrow Articles by Flamand, A.
Agricola
Right arrow Articles by Coulon, P.
Right arrow Articles by Flamand, A.

Molecular Basis of Rabies Virus Virulence. II. Identification of a Site on the CVS Glycoprotein Associated with Virulence

P. Coulon1, P. E. Rollin2 and A. Flamand1

1 Bâtiment 400, Université de Paris-Sud, 91405 Orsay Cedex, France
2 Institut Pasteur, Centre Antirabique, 28 rue du Dr Roux, 75724 Paris Cedex 15, France

Nine anti-G monoclonal antibodies were used to select mutants of the CVS strain of rabies virus resistant to neutralization. Seven mutants were avirulent in adult mice and two others exhibited an attenuated pathogenicity. Both categories were resistant to monoclonal antibodies 194-2 and 248-8. Virulence appears to be associated with a particular configuration of a region of the glycoprotein which is located at the intersection of the epitopes recognized by these two monoclonal antibodies. Our results confirm the role played by the glycoprotein in the neurovirulence of rabies virus.

Keywords: avirulent mutants, rabies virus, monoclonal antibody, glycoprotein

Received 12 August 1982; accepted 7 October 1982.


This article has been cited by other articles:


Home page
 J. Virol.Home page
R. Pulmanausahakul, J. Li, M. J. Schnell, and B. Dietzschold
The Glycoprotein and the Matrix Protein of Rabies Virus Affect Pathogenicity by Regulating Viral Replication and Facilitating Cell-to-Cell Spread
J. Virol., March 1, 2008; 82(5): 2330 - 2338.
[Abstract] [Full Text] [PDF]

Home page
 J. Gen. Virol.Home page
T. Irie and A. Kawai
Studies on the different conditions for rabies virus neutralization by monoclonal antibodies #1-46-12 and #7-1-9
J. Gen. Virol., December 1, 2002; 83(12): 3045 - 3053.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
P. C. Roberts, T. Kipperman, and R. W. Compans
Vesicular Stomatitis Virus G Protein Acquires pH-Independent Fusion Activity during Transport in a Polarized Endometrial Cell Line
J. Virol., December 1, 1999; 73(12): 10447 - 10457.
[Abstract] [Full Text]

Home page
 J. Gen. Virol.Home page
Y Gaudin, P de Kinkelin, and A Benmansour
Mutations in the glycoprotein of viral haemorrhagic septicaemia virus that affect virulence for fish and the pH threshold for membrane fusion
J. Gen. Virol., May 1, 1999; 80(5): 1221 - 1229.
[Abstract]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
INT J SYST EVOL MICROBIOL MICROBIOLOGY J GEN VIROL
J MED MICROBIOL ALL SGM JOURNALS
Copyright © 1983 by the Society for General Microbiology.