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1 ARC & MRC Neuropathogenesis Unit, Edinburgh EH9 3JQ
2 Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP
3 ARC Institute for Research on Animal Diseases, Compton, Newbury RG16 0NN, U.K.
The onset of replication has been studied in spinal cord, dorsal root ganglia and spinal nerves of CW mice infected intraperitoneally with the 139A strain of scrapie. The patterns obtained suggest a centrifugal spread of infection from central to peripheral nervous systems. Infectivity titres in the peripheral nervous system reached a plateau long before the end of the incubation period, and the maximum titres were much lower than in the central nervous system. This suggests that there is a restriction of replication in the peripheral nervous system similar to that already known in extraneural tissues.
Keywords: scrapie, pathogenesis, centrifugal infection, nervous system
Received 12 August 1982;
accepted 13 October 1982.
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