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Virus-induced Diabetes Mellitus. XXV. Difference in the RNA Fingerprints of Diabetogenic and Non-diabetogenic Variants of Encephalomyocarditis Virus

Laboratory of Oral Medicine, National Institute of Dental Research
and¹ Laboratory of Molecular Biology, National Institute of Neurological and Communicative Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20205, U.S.A.

The genomes of diabetogenic and non-diabetogenic variants of encephalomyocarditis virus were analysed by nucleic acid hybridization and RNA fingerprinting. Hybridization and thermal elution profiles failed to show any difference between the RNAs of the two variants, whereas fingerprinting of the T1-digested RNAs revealed at least one oligonucleotide, 20 to 25 nucleotides long, missing in the non-diabetogenic variant.

Keywords: encephalomyocarditis virus, diabetes, cDNA-RNA hybridization

Received 25 June 1982; accepted 16 November 1982.