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Effects of Retrovirus Protein on the Feline One-way Mixed Leukocyte Reaction

¹ Department of Veterinary Pathobiology, The Ohio State University, 1925 Coffey Road, Columbus, Ohio 43210
and² Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210, U.S.A.

The objective of this study was to evaluate the effects of feline retrovirus protein on cat lymphocyte recognition of allogeneic cells in the mixed leukocyte reaction (MLR), using u.v.-inactivated feline leukaemia virus (FeLV) and a non-disease-producing endogenous cat virus (RD-114). Twenty micrograms of u.v.-inactivated virus protein from each virus were added to mixed leukocyte cultures. FeLV induced significant suppression of the MLR (P < 0.005) whereas no significant suppression was found using RD-114. Since feline leukaemia infection is associated with immunosuppression, the retrovirus proteins may be interfering with the response of immunocompetent cells when they are confronted with an altered host cell.

Keywords: FeLV, MLR, retrovirus, immunosuppression

Received 18 June 1982; accepted 3 December 1982.