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Most Virus-specific Polypeptides in Cells Productively Infected with Marek's Disease Virus or Herpesvirus of Turkeys Possess Cross-reactive Determinants

Department of Pathology, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka 565, Japan
and¹ Department of Molecular Biology, Tokai University School of Medicine, Bohseidai, Isehara 259-11, Japan

Most virus-specific polypeptides in cells productively infected with Marek's disease virus (MDV) or herpesvirus of turkeys (HVT) possess cross-reactive antigenic determinants, although the two viruses have very little DNA homology. The cross-reactivity appeared to be more evident when [³⁵S]methionine-labelled polypeptides were immunoprecipitated than when the [³H]glucosamine-labelled polypeptides were immunoprecipitated, suggesting that the glycoproteins of MDV and HVT may be less related in structure than other proteins. The major cross-reactive glycoproteins excreted into the culture mediums of MDV- and HVT-infected cells had molecular weights of 64000 (gp64) and 56000 (gp56) respectively.

Keywords: Marek's disease virus, herpesvirus of turkeys, cross-reactivity

Received 23 August 1982; accepted 29 November 1982.

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