HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Thorne, H. V. Articles by Clarke, G. F. Search for Related Content PubMed PubMed Citation Articles by Thorne, H. V. Articles by Clarke, G. F. Agricola Articles by Thorne, H. V. Articles by Clarke, G. F.

Inactivation of Measles and Herpes Simplex Viruses by Trypan Blue

Department of Microbiology and Immunobiology, The Queen's University of Belfast, Grosvenor Road, Belfast BT12 6BN, U.K.

The dye trypan blue inhibits infection of cells in tissue culture by measles and herpes simplex viruses at concentrations in excess of 0.01% (w/v) principally by direct inactivation of the virions. The inactivation is temperature-dependent (10⁴ times greater at 37 °C than at 4 °C) and its mechanism appears to include inhibition of virus adsorption to cells.

Keywords: measles virus, HSV, trypan blue, antiviral activity

^* Virus preparations were infected cell homogenates clarified by centrifugation for 20 min at 3000 g.

Received 18 October 1982; accepted 21 January 1983.