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Failure to Modify Scrapie in Mice by Administration of Interferon or Anti-interferon Globulin

Laboratory of Viral Oncology, Institut de Recherches Scientifiques sur le Cancer, BP 8, 94802 Villejuif, France
and¹ Agricultural Research Council, Institute for Research on Animal Diseases, Compton, Nr Newbury, Berkshire, U.K.

Administration of potent mouse interferon preparations or anti-mouse interferon globulin did not influence the evolution of scrapie in mice after intraperitoneal injection of the agent. We conclude that the interferon system is probably not involved in scrapie.

Keywords: scrapie, interferon, anti-interferon globulin

Received 29 November 1982; accepted 19 January 1983.

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