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Generation and Characterization of a Non-defective Interfering Particle of Vesicular Stomatitis Virus: Homotypic and Heterotypic Interference

Gary J. Williams

Department of Microbiology, School of Medicine, State University of New York at Buffalo, Buffalo, New York 14214, U.S.A.

Serial undiluted passages of vesicular stomatitis virus in African green monkey kidney (CV-1) cells resulted in the generation of a small-plaque-forming mutant. This mutant has been characterized as a non-defective particle with homotypic and heterotypic interference properties.

Keywords: VSV mutant, non-defective interfering particle, interference, small-plaque mutant

Present address: Department of Microbiology and Immunology, School of Medicine, Washington University, St. Louis, Missouri 63110, U.S.A.

Received 28 October 1982; accepted 30 December 1982.