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Monoclonal Antibodies against Human Paramyxovirus Type 3 and against SV5 Virus: Preparation and Preliminary Characterization

K. K. A. Goswami

Division of Virology, National Institute for Medical Research, Mill Hill, London NW7 1AA, U.K.

Monoclonal antibodies against the major glycoprotein (HN) and the nucleoprotein (NP) of paramyxovirus SV5 and human paramyxovirus (PF) type 3 have been obtained. Two different epitopes have been detected on the SV5 HN polypeptide, one being specific to SV5 and the other also cross-reacting with PF-2 HN polypeptide. Monoclonal antibody against SV5 NP polypeptide also reacted with PF-2 NP polypeptide. Similar epitopes showing both specific and group cross-reactions were detected with PF-3 HN and NP monoclonal antibodies against PF-3 and Sendai viruses. No cross-reactions were detected between these two groups of paramyxoviruses.

Keywords: monoclonal antibodies, SV5, parainfluenza virus type 3

Present address: Brompton Hospital, Fulham Road, London, U.K.

Received 10 March 1983; accepted 3 May 1983.