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Monoclonal Antibodies Against La Crosse Virus

Center for Laboratories and Research, New York State Department of Health, Albany, New York 12201, U.S.A.

Monoclonal antibodies have been used to show that an epitope is present on the G₁ glycoprotein of prototype La Crosse virus that is absent or significantly altered on several isolates of La Crosse virus made in New York State, U.S.A. The portion of the G₁ protein where this epitope is located plays a role in both virus neutralization and haemagglutination. Additional experiments revealed that under the appropriate assay conditions the monoclonal antibodies permitted discrimination between representatives of the North American members of the California serogroup.

Keywords: California serogroup viruses, La Crosse virus, monoclonal Abs

Received 8 February 1983; accepted 18 April 1983.

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