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Comparative Antiproliferative Efficacies of Human and Interferons

Memorial Sloan-Kettering Cancer Center, New York, New York 10021, U.S.A.

The cell growth inhibitory efficacies of preparations of human and interferons (IFNs) have been tested on a variety of human cell lines. Human IFN- was found to be more effective at inhibiting the growth of HeLa and U-amnion cells than was human IFN-. The Daudi cell line, on the other hand, which exhibits a strong anticellular effect in response to treatment with human IFN-, was found to be relatively insensitive to the anticellular effect of human IFN-, as were a variety of other lymphoid cell lines. The inability of the IFN- to inhibit the growth of the Daudi cells is paralleled by its inability to induce the synthesis of proteins observed to be synthesized in these cells in response to IFN-.

Keywords: human IFNs, antiproliferative effects, induced proteins, differential responsiveness

Received 19 October 1982; accepted 25 February 1983.