HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Cantell, K. Articles by Schellekens, H. Search for Related Content PubMed PubMed Citation Articles by Cantell, K. Articles by Schellekens, H. Agricola Articles by Cantell, K. Articles by Schellekens, H.

Circulating Interferon in Rabbits and Monkeys after Administration of Human Gamma Interferon by Different Routes

National Public Health Institute, SF 00280, Helsinki 28, Finland
and¹ Primate Center TNO, 2280 HV Rijswijk, The Netherlands

Rabbits and rhesus monkeys were injected with 3 x 10⁵ units of human gamma interferon (IFN) prepared in human leukocyte suspensions. Circulating IFN was detected up to 4 h after intravenous administration. Intramuscular injection maintained a relatively stable serum IFN level of about 50 units/ml for 7 to 9 h. The results in both species were similar. Little or no circulating IFN was detected after subcutaneous injection of 3 x 10⁵ units, but 1.5 x 10⁶ units maintained about 50 units per ml of serum for 30 h. Pharmacokinetically, human gamma IFN resembled human alpha interferons rather than human beta IFN.

Keywords: interferon (HuIFN-), pharmacokinetics, rabbits, monkeys

Received 11 February 1983; accepted 9 May 1983.

This article has been cited by other articles:

				H. Ozwara, J. A. M. Langermans, C. H. M. Kocken, A. van der Wel, P. H. van der Meide, R. A. W. Vervenne, J. M. Mwenda, and A. W. Thomas Transfected Plasmodium knowlesi Produces Bioactive Host Gamma Interferon: a New Perspective for Modulating Immune Responses to Malaria Parasites Infect. Immun., August 1, 2003; 71(8): 4375 - 4381. [Abstract] [Full Text] [PDF]

				D. Xu, S. J. McSorley, L. Tetley, S. Chatfield, G. Dougan, W. L. Chan, A. Satoskar, J. R. David, and F. Y. Liew Protective Effect on Leishmania major Infection of Migration Inhibitory Factor, TNF-{alpha}, and IFN-{gamma} Administered Orally via Attenuated Salmonella typhimurium J. Immunol., February 1, 1998; 160(3): 1285 - 1289. [Abstract] [Full Text] [PDF]