J Gen Virol Email Content Delivery
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Gen Virol 64 (1983), 1839-1847; DOI 10.1099/0022-1317-64-9-1839
© 1983 Society for General Microbiology
This Article
Right arrow Full Text (PDF)
Right arrow Corrigendum (v65,p252)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Blumberg, B. M.
Right arrow Articles by Kolakofsky, D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Blumberg, B. M.
Right arrow Articles by Kolakofsky, D.
Agricola
Right arrow Articles by Blumberg, B. M.
Right arrow Articles by Kolakofsky, D.

An Analytical Review of Defective Infections of Vesicular Stomatitis Virus

Benjamin M. Blumberg and Daniel Kolakofsky

Department of Microbiology, University of Geneva Medical School, 64 Avenue de la Roseraie, CH-1205 Geneva, Switzerland

Introduction. Following the discovery of interference in influenza infections by incomplete forms of the virus (von Magnus, 1951), Cooper & Bellett (1959) found a similar phenomenon in vesicular stomatitis virus (VSV) infections, and showed that it was due to transmissible components, defective interfering (DI) particles (Hackett, 1964; Huang & Wagner, 1966), which are usually generated when VSV is passaged at a high multiplicity of infection (m.o.i.). DI particles can replicate only during co-infection with standard or non-defective (ND) helper virus, and in such mixed virus infections the replication of the helper virus is greatly repressed. Bellett & Cooper (1959) observed a reciprocal exponential relationship between the m.o.i. of DI particles in the inoculum and the yield of infectious virion progeny, and deduced that co-infection of a cell with a single DI particle is sufficient to repress the helper virus in one passage (compare Sekellick & Marcus, 1980). DI particles enjoy a replicative advantage over ND virions, and once generated they quickly become the dominant viral species during high m.o.i. passage.

Keywords: VSV, interference, mathematical analysis






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
INT J SYST EVOL MICROBIOL MICROBIOLOGY J GEN VIROL
J MED MICROBIOL ALL SGM JOURNALS
Copyright © 1983 by the Society for General Microbiology.