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Sensitivity of Ovine Choroid Plexus Cells to Human and Other Animal Interferons

Department of Microbiology and Pathology, College of Veterinary Medicine, Washington State University, Pullman, Washington 99164, U.S.A.

The sensitivity of ovine choroid plexus cells to the antiviral effects of the three major types of human and other animal interferons (IFNs) was tested. Ovine cells were found to be highly sensitive to the antiviral effects of natural human IFN- and IFN- but not IFN-. In addition, ovine cells were highly sensitive to recombinant DNA-derived human IFN-₂, IFN-₁ and IFN-. Furthermore, ovine cells were more sensitive (P < 0.01) to human IFN-s than human fibroblasts (trisomic or disomic for chromosome 21) or bovine cells. Moreover, ovine cells were found to be highly sensitive to the three natural types of bovine, caprine, equine and porcine IFN preparations and relatively insensitive to mouse L-cell IFN.

Keywords: interferons (HuIFN), sensitivity, antiviral effect, ovine cells

Received 15 December 1982; accepted 9 May 1983.