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Interferon Production Associated with the Ageing of Primary Chick Embryo Cells Is Not Caused by Priming

Department of Measles Virus, National Institute of Health of Japan, 4-7-1, Gakuen, Musashimurayama-shi, Tokyo 190-12, Japan

The presence of a low level of interferon (IFN) activity was demonstrated in aged culture medium of primary chick embryo (CE) cells. The endogenous cytoplasmic level of 2',5'-oligoadenylate (2',5'-A) synthetase activity also increased during cell ageing. This increase was suppressed by addition of antiserum against chick IFN. In contrast, anti-chick IFN serum did not inhibit the ageing effect, i.e. the enhanced production of IFN upon induction after a prolonged preincubation of CE cells. This result indicates that the occurrence of the ageing effect is not mediated by the IFN system which had been expressed spontaneously.

Keywords: IFN, chick cells, ageing, priming

Received 28 February 1983; accepted 20 May 1983.