HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Godard, C. M. Articles by Jasmin, C. Search for Related Content PubMed PubMed Citation Articles by Godard, C. M. Articles by Jasmin, C. Agricola Articles by Godard, C. M. Articles by Jasmin, C.

Expression of Ecotropic Murine Leukaemia Virus in Haemopoietic Cells of AKR Mice during the Embryonic and Neonatal Period

Institut de Cancérologie et d'Immunogénétique (INSERM U.50), Hôpital Paul-Brousse, 14–16 avenue Paul-Vaillant-Couturier, 94804 Villejuif, France

Cells which produce ecotropic murine leukaemia virus have been detected in the bone marrow and the spleen of weanling AKR mice, using an infectious centre technique based on the XC test. There is a noticeable increase in the number of virusproducing cells between day 3 and day 12 after birth, in both of these organs. Some of the virus-producing cells that appear after day 3 have been identified as haemopoietic precursor cells of the granulocyte-macrophage blood lineage. Such precursor cells do not produce virus during the embryonic period and they progressively become involved in virus production after day 3. By day 12, all of them are active virus producers. Thus, the ecotropic virus is expressed in precursor cells of the haemopoietic system, and the latter represent at least one-third of the virus-producing cells in the bone marrow of young AKR mice.

Keywords: AKR MuLV, haemopoietic cells, retrovirus expression, neonatal

Received 14 January 1983; accepted 31 May 1983.