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The Role of Phosphorylation and Core Protein V in Adenovirus Assembly

Govindranathsing Khittoo

Départment de Microbiologie, Centre Hospitalier, Universitaire de Sherbrooke, Sherbrooke, Québec, Canada J1H 5N4

The role of phosphorylation and the minor core protein V in adenovirus type 2 assembly was examined. Comparison of the phosphoprotein composition of top components (TC), young virions and mature virions of wild-type and assembly mutants showed specific changes related to virus assembly and maturation. TC were identified as precursors of young virions which contain two molecular weight forms of core protein V, one of which is phosphorylated. Conversion of TC into young virions by DNA encapsidation resulted in the loss of the unphosphorylated form of protein V, and subsequent maturation to old virions resulted in the dephosphorylation of the core protein. This last step is blocked by the ts1 mutation which inactivates the viral endoproteinase.

Keywords: adenovirus, phosphoproteins, core proteins, virus assembly

Present address: Department of Biochemical Sciences, Princeton University, New Jersey, U.S.A.

Received 16 February 1983; accepted 16 May 1983.

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