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The Characterization of Monoclonal Antibodies to Newcastle Disease Virus

¹ Department of Microbiology and Parasitology, Royal Veterinary College, Royal College Street, London NW1 0TU
² Division of Virology, National Institute for Medical Research, Mill Hill, Loindon NW7 1AA
and³ Poultry Department, Central Veterinary Laboratory, New Haw, Weybridge, Surrey, U.K.

Monoclonal antibodies to the haemagglutinin—neuraminidase (HN), fusion (F), polymerase and nucleocapsid polypeptides of Newcastle disease virus were prepared. Two epitopes were recognized on the HN polypeptide: one was associated with inhibition of haemagglutination and poor neutralization and the other with good neutralization and no inhibition of haemagglutination. The most effective neutralizing antibody was that produced against the F polypeptide. The poorer neutralization associated with the antibody against the HN epitope was augmented by antiglobulin or complement. The monoclonal antibodies that inhibited haemagglutination also inhibited neuraminidase activity when fetuin but not neuraminyl lactose was the substrate.

Keywords: NDV, monoclonal Abs, polymerase, neutralization

Received 24 February 1983; accepted 31 May 1983.

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