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Intranuclear Distribution of Herpes Simplex Virus Type 2 DNA Synthesis: Examination by Light and Electron Microscopy

J. Hay

MRC Virology Unit, Institute of Virology, University of Glasgow, Church Street, Glasgow G11 5JR, U.K.

Uptake of [³H]thymidine by serum-starved baby hamster kidney cells infected with herpes simplex virus type 2 was investigated by light microscopic and electron microscopic autoradiography. The distribution of incorporated label altered throughout the period of viral DNA synthesis. It was restricted initially to a few well-defined sites within the nucleus which increased in size and spread as infection proceeded until the entire nucleus was involved. The label was not associated with any identifiable subnuclear structure although there was a high degree of association with the nuclear membrane at early times post-infection.

Keywords: HSV-2 DNA synthesis, autoradiography, light microscope, electron microscope

Present address: Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, Maryland 20814, U.S.A.

Received 21 April 1983; accepted 31 May 1983.

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