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Demonstration of Neutralizing and Non-neutralizing Epitopes on the Trypsin-sensitive Site of Foot-and-Mouth Disease Virus

The Wellcome Foot and Mouth Disease Vaccine Laboratory, Ash Road, Pirbright, Woking, Surrey, GU24 0NQ, U.K.

The isolation of monoclonal antibodies directed against the trypsin-sensitive site on the 140S particle of foot-and-mouth disease virus (FMDV) has enabled the demonstration of at least three distinct epitopes within this site. Reaction with two of these resulted in neutralization of virus infectivity. None of the epitopes appeared to be present on the 12S particles, and one of the neutralizing epitopes was sensitive to even milder configurational changes of the particle.

Keywords: FMDV, epitopes, trypsin-sensitive site

Received 7 June 1983; accepted 19 September 1983.