J Gen Virol Email Content Delivery
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Gen Virol 65 (1984), 65-71; DOI 10.1099/0022-1317-65-1-65
© 1984 Society for General Microbiology
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Freebeck, P. C.
Right arrow Articles by O'Brien, T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Freebeck, P. C.
Right arrow Articles by O'Brien, T.
Agricola
Right arrow Articles by Freebeck, P. C.
Right arrow Articles by O'Brien, T.

An Ultrastructural Examination of Non-lymphoid Host Cells of Moloney Murine Leukaemia Virus of CFW/D Mice

Peter C. Freebeck*, Roderick MacLeod and Timothy O'Brien

Department of Biology and Department of Genetics and Development, School of Basic Medical Sciences, University of Illinois, Urbana, Illinois 61801, U.S.A.

An ultrastructural examination of various tissues from CFW/D mice, neonatally injected with Moloney murine leukaemia virus (Mo-MuLV) revealed the presence of type C virus particles budding from the membranes of various bone marrow-derived cells, pancreatic acinar cells, beta cells, and submandibular gland acinar cells. These observations indicate that Mo-MuLV has the potential to replicate in non-lymphoid cell types even when acquired post-partum. In the pancreas, a large accumulation of immature and mature viral particles was observed between the cell membranes of the acinar cells and the basal lamina. A similar accumulation of viral particles was observed in the lumina of the acinus of submandibular glands. The role of murine leukaemia viruses as potential mediators of aberrations of non-haemopoietic tissues and an alternative mode of viral transmission are discussed.

Keywords: Mo-MuLV, ultrastructure, distribution, transmission

* Mailing address: 847 East 57th Street, Chicago, Illinois 60637, U.S.A.

Received 10 August 1983; accepted 22 September 1983.




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
INT J SYST EVOL MICROBIOL MICROBIOLOGY J GEN VIROL
J MED MICROBIOL ALL SGM JOURNALS
Copyright © 1984 by the Society for General Microbiology.