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Modulation of a Systemic Semliki Forest Virus Infection in Mice by Defective Interfering Virus

Department of Biological Sciences, University of Warwick, Coventry CV4 7AL, U.K.

Evidence is presented that defective interfering (DI) Semliki Forest virus (SFV) can modulate the systemic infection in mice initiated by intraperitoneal inoculation of 10 LD₅₀ SFV. Either the mean time of death was delayed or mice failed completely to develop any sign of disease. This prophylactic activity of DI virus was not due to the stimulation of an adaptive immune response since an equivalent amount of non-infectious virus antigen did not change the course of disease.

Keywords: SFV, DI virus, modulation, pathogenicity

Received 26 April 1984; accepted 13 July 1984.