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Cells Infected with Human Cytomegalovirus Release a Factor(s) that Stimulates Cell DNA Synthesis

The Wistar Institute of Anatomy and Biology, 36th Street at Spruce, Philadelphia, Pennsylvania 19104, U.S.A.

Culture supernatants of permissive and non-permissive cells infected with human cytomegalovirus (HCMV) contain a growth factor that enhances the DNA synthesis and mitotic activity of target cells. This cytomegalovirus growth factor (CMV-GF) is a heat-stable, acid-labile polypeptide that is sensitive to trypsin and dithiothreitol. CMV-GF is an early product of the infected cells and defective virions are primarily responsible for its induction. Microtubule depolymerization is necessary for the induction of DNA synthesis by the CMV-GF, since taxol, an inhibitor of microtubule depolymerization, blocks its effect.

Keywords: growth factor, cytomegalovirus, DNA synthesis, stimulation

Received 24 January 1984; accepted 25 June 1984.

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