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J Gen Virol 65 (1984), 1845-1849; DOI 10.1099/0022-1317-65-10-1845
© 1984 Society for General Microbiology
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Adaptation of Borna Disease Virus to the Mouse

Moujahed Kao, Hanns Ludwig and Georg Gosztonyi1

1 Institutes of Virology and Neuropathology, Free University of Berlin, Nordufer 20, (Robert Koch-Institut), 1000 Berlin 65, and Hindenburgdamm 30, 1000 Berlin 45, Federal Republic of Germany

Borna disease virus has been adapted to the mouse, which required at least three passages in rat brains. Genetic specificity as studied with five inbred mouse strains was not evident. Newborn mice inoculated intracerebrally expressed antigen in neurons and remained persistently infected, with up to 107 infectious units per gram of brain tissue. Animals infected at different ages developed no disease and had high titres of antibodies.

Keywords: Borna disease, persistent tolerant infection, adaptation

Received 3 April 1984; accepted 18 June 1984.


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