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J Gen Virol 65 (1984), 2259-2264; DOI 10.1099/0022-1317-65-12-2259
© 1984 Society for General Microbiology
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Human Adult T-Cell Leukaemia Virus Is Distinct from a Similar Isolate of Japanese Monkeys

Naoki Yamamoto1, Morihisa Okada1, Yorio Hinuma1, Friedrich W. Hirsch2, Toru Chosa3, Josef Schneider3 and Gerhard Hunsmann3

1 Institute for Virus Research, Kyoto University, Kyoto 606, Japan
2 Medizinische Klinik Universität Freiburg, Federal Republic of Germany
and3 Deutsches Primatenzentrum, Abteilung Virologie und Immunologie, Kellnerweg 4, D-3400 Göttingen, Federal Republic of Germany

We have compared the structural polypeptides of an adult T-cell leukaemia (ATL) virus (ATLV) isolate from a Japanese patient with ATL with those of a similar virus derived from a Japanese macaque monkey. Both are distinct but related entities. Their core polypeptides p19 could not be distinguished, but p24, another core polypeptide, and their envelope glycopolypeptides differ. The human virus directs the synthesis of a single intracellular glycopolypeptide, gp68, while the macaque virus specifies two such glycopolypeptides, gp57 and gp50. Furthermore, the glycopolypeptides of both viruses are serologically distinct. Thus, these viruses represent subtypes of the ATLV family and the macaque virus is apparently not involved in human ATL.

Keywords: ATLV, monkey, polypeptides

Received 2 April 1984; accepted 15 August 1984.


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M. Daniel, N. Letvin, N. King, M Kannagi, P. Sehgal, R. Hunt, P. Kanki, M Essex, and R. Desrosiers
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[Abstract] [PDF]


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