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The Reticuloendothelial System in Scrapie Pathogenesis

Roland Rudolph

Robert Koch-Institut des Bundesgesundheitsamtes, Nordufer 20, D-1000 Berlin 65, Federal Republic of Germany

A single injection of 1 mg dextran sulphate 500 per mouse considerably prolonged incubation times and produced survivors, even when given 3 days after intravenous or intraperitoneal scrapie infection. Since this compound could be detected in mononuclear phagocytes of spleen and lymph nodes for up to 7 months, it is suggested that it impairs a particular step in the infectious process in these cells of the lymphoreticular system. Blockage of the reticuloendothelial system by trypan blue and silica did not alter the pathogenesis.

Keywords: scrapie, dextran sulphate, reticuloendothelial system

Present address: Institut für Veterinär-Pathologie, Freie Universität Berlin, Drosselweg 1-3, D-1000 Berlin 33, F.R.G.

Received 5 September 1983; accepted 28 October 1983.

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