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The Reaction of the Anti-interferon- Monoclonal Antibody, NK2, with Different Interferons

Department of Biological Sciences, University of Warwick, Coventry CV4 7AL, U.K.

Analysis of the neutralization of human interferon- by the monoclonal antibody NK2 showed, by three different methods, that the avidity constant was about 10¹⁰ M^-1. A small decrease in the avidity constant (and in the antibody titre) with increasing interferon concentrations was observed, suggesting that the antibody-interferon complex had a little biological activity. The antibody neutralizes the interferon by preventing the binding of interferon to susceptible cells. It does not react with human-, mouse-, monkey, bovine or rabbit interferons.

Keywords: IFNs, monoclonal antibody, avidity constant

Received 19 July 1983; accepted 14 December 1983.