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J Gen Virol 65 (1984), 645-649; DOI 10.1099/0022-1317-65-3-645
© 1984 Society for General Microbiology
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Berne Virus is Not ‘Coronavirus-like’

M. C. Horzinek, M. Weiss1 and J. Ederveen

Institute of Virology, Veterinary Faculty, State University, Utrecht, Yalelaan 1, 3508 TD Utrecht, The Netherlands
and1 Virology Department, Institute of Bacteriology, Veterinary Faculty, University of Berne, Switzerland

In infected embryonic mule skin cells, Berne virus directs the synthesis of two main polypeptides (22K, 20K); in addition, virus-specific proteins with apparent molecular weights of >200K, 80K to 120K, 32K and 17K were detected after radioimmune precipitation. The replication of Berne virus was reduced more than 1000-fold by actinomycin D, when the drug (0.1 to 1.0 µg/ml) was added during the first 8 h after infection; alpha-amanitin (25 µg/ml) produced a similar though less pronounced effect. U.v. preirradiation of the cells for >= 5s led to a dramatic decrease in the production of extracellular virus. The results presented support our suggestion that Berne virus is a representative of a new family of animal viruses.

Keywords: Berne virus, polypeptides, inhibitors

Received 21 September 1983; accepted 21 November 1983.


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S Resta, J. Luby, C. Rosenfeld, and J. Siegel
Isolation and propagation of a human enteric coronavirus
Science, September 6, 1985; 229(4717): 978 - 981.
[Abstract] [PDF]


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