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J Gen Virol 65 (1984), 761-767; DOI 10.1099/0022-1317-65-4-761
© 1984 Society for General Microbiology
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Purification and Characterization of GP90, One of the Envelope Glycoproteins of Respiratory Syncytial Virus

Edward E. Walsh, Jacob J. Schlesinger and Michael W. Brandriss

Department of Medicine, The Rochester General Hospital and the University of Rochester School of Medicine and Dentistry, Rochester, New York 14621, U.S.A.

The large glycoprotein, GP90, of respiratory syncytial virus (RSV) was purified by affinity chromatography using a monoclonal antibody. Hyperimmune rabbit antiserum directed specifically to the purified GP90 neutralized RSV to high titre but did not inhibit fusion of previously infected cells. 125I-labelled GP90 bound rapidly to HEp-2 cells in an unsaturable manner; binding was inhibited by the hyperimmune rabbit antiserum.

Keywords: RSV, glycoprotein, purification

Received 20 October 1983; accepted 16 January 1984.


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