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Newcastle Disease Virus: the Effect of Monoclonal Antibody in the Overlay on Virus Penetration and the Immunoselection of Variants

Department of Microbiology and Parasitology, The Royal Veterinary College (University of London), Royal College Street, London NW1 0TU, U.K.

Monoclonal antibody to the haemagglutinin—neuraminidase or the fusion glycoprotein of Newcastle disease virus blocked virus penetration which otherwise occurred within 90 s of the temperature being increased from 4 °C to 37 °C. These antibodies regularly immunoselected variant plaques only when incorporated into the agarose overlay. Variant viruses then formed plaques whereas the growth of non-neutralized normal virus was suppressed.

Keywords: NDV variants, neutralization, monoclonal antibody, penetration time

Received 14 October 1983; accepted 6 January 1984.

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