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J Gen Virol 65 (1984), 859-863; DOI 10.1099/0022-1317-65-5-859
© 1984 Society for General Microbiology
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Determination of the Sequence Alteration in the DNA of the Herpes Simplex Virus Type 1 Temperature-sensitive Mutant ts K

M.-J. Davison1, V. G. Preston1,2, and D. J. McGeoch1,2,

1 Institute of Virology
and2 MRC Virology Unit, University of Glasgow, Church Street, Glasgow G11 5JR, U.K.

The alteration in the DNA sequence responsible for the mutant phenotype of the herpes simplex virus type 1 temperature-sensitive mutant ts K has been determined. A single C:G base pair present in the wild-type Vmw 175 immediate-early polypeptide-coding sequence has been replaced by T:A in the mutant gene. This results in the substitution of an alanine by a valine codon. In two revertants the mutant T:A base pair has been resubstituted by C:G.

Keywords: HSV-1 ts K, marker rescue, Vmw 175

Received 29 December 1983; accepted 7 February 1984.


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