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Central Veterinary Laboratory, New Haw, Weybridge, Surrey
and1 Sir William Dunn School of Pathology, University of Oxford, U.K.
The suggestion that antibodies might enhance rabies virus infection of macrophages through opsonization of immune complexes was tested in vitro by adaptation of the rapid fluorescent focus inhibition technique for the examination of a macrophage cell line (P388D1). Some enhancement of rabies virus infection was shown. The relationship between such enhancement with the ‘early death’ phenomenon and its occurrence in vivo is discussed.
Keywords: rabies, antibody-mediated enhancement, RFFIT
Received 5 September 1983;
accepted 22 February 1984.
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