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J Gen Virol 65 (1984), 1095-1100; DOI 10.1099/0022-1317-65-6-1095
© 1984 Society for General Microbiology
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Theiler's Virus-specified Polypeptides Made in BHK-21 Cells

Howard L. Lipton, Edward J. Rozhon and Donald Black1

Department of Neurology, Northwestern University Medical School, 303 East Chicago Avenue, Chicago, Illinois 60611, U.S.A.
and1 Animal Virus Research Institute, Pirbright, Woking, Surrey, U.K.

This study was initiated to determine whether the Theiler's murine encephalomyelitis viruses (TMEV) use the same strategy of gene expression as other picornaviruses. The precursor-product relationships apparent from pulse-chase experiments indicated that the virus-specified polypeptides of the GDVII strain are generated by post-translational cleavages. Pactamycin mapping experiments also showed a gene order for GDVII virus similar to that derived for other picornaviruses by this technique. Finally, six other TMEV induced species of polypeptides similar to those of GDVII virus, but there were minor differences in some of their electrophoretic mobilities.

Keywords: Theiler's virus, enterovirus, pactamycin, neurovirulence

Received 7 November 1983; accepted 23 February 1984.


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C. Badshah, M. A. Calenoff, and K. Rundell
The Leader Polypeptide of Theiler's Murine Encephalomyelitis Virus Is Required for the Assembly of Virions in Mouse L Cells
J. Virol., January 1, 2000; 74(2): 875 - 882.
[Abstract] [Full Text]


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