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Propagation of Human Candidate Calicivirus in Cell Culture

Public Health Laboratory and Department of Microbiology, Central Middlesex Hospital, Park Royal, London NW10 7NS
and¹ Department of Biological Sciences, University of Warwick, Coventry CV4 7AL, U.K.

Evidence is presented for the first time that a human candidate calicivirus (HCV) replicates in human embryo kidney cells when trypsin is incorporated in the culture medium. The virus multiplies in the presence of actinomycin D and radiolabelling experiments with [³H]uridine indicate that it has an RNA genome. These observations provide further support for the view that HCV should be tentatively classified as a member of the Caliciviridae.

Keywords: calicivirus, human, trypsin

Received 13 December 1983; accepted 8 March 1984.

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