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Effect of Recombinant DNA-produced Bovine Interferon Alpha (BoIFN-₁) on the Interaction between Bovine Alveolar Macrophages and Bovine Herpesvirus Type 1

Department of Veterinary Microbiology, Western College of Veterinary Medicine, University of Saskatchewan, and Veterinary Infectious Disease Organization, Saskatoon, Saskatchewan, Canada, S7N 0WO

Treatment of bovine alveolar macrophages (BAM) with bovine leukocyte interferon (BoIFN-₁) resulted in reduced bovine herpesvirus type 1 replication and spread. This was demonstrated by reduced virus yields and number of cells infected. BoIFN-₁ treatment of BAM also induced enhanced Fc receptor expression and/or avidity by the cells, increased their activity in antibody-dependent cellular cytotoxicity, and augmented their extrinsic antiviral activity as measured by a reduction in the development of plaques in a susceptible cell line. These results are discussed in the context of the possible role of interferon in activation of AM during the early phases of a virus infection.

Keywords: interferon (BoIFN-₁), alveolar macrophages, BHV-1

Received 21 March 1984; accepted 4 June 1984.

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