HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Duchesne, M. Articles by Fallourd, A. Search for Related Content PubMed PubMed Citation Articles by Duchesne, M. Articles by Fallourd, A. Agricola Articles by Duchesne, M. Articles by Fallourd, A.

Localization of a Neutralization Epitope of Foot-and-Mouth Disease Virus Using Neutralizing Monoclonal Antibodies

Laboratoire Roger Bellon, 18, rue de Montbazon, 37260 Monts, France

Neutralizing monoclonal antibodies raised against intact foot-and-mouth disease virus reacted with intact particles and with isolated VP1 from different strains from the same subtype. Prior treatment of the virus with either trypsin or with arginine-specific protease abolished recognition of both the virus and of VP1, suggesting the presence of a neutralization epitope in the central region of VP1 cleaved by these two enzymes. A synthetic peptide analogue of part of this region showed poor reactivity, however, with neutralizing antibody.

Keywords: FMDV, neutralization epitope, monoclonal antibodies

Received 4 January 1984; accepted 23 May 1984.