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Monoclonal Antibodies to Herpes Simplex Virus Thymidine Kinase

MRC Herpes Virus Research Group, Department of Microbiology, University of Leeds, Leeds LS2 9JT, U.K.
and¹ G.D. Searle and Co. Ltd., Research and Development Division, Lane End Road, High Wycombe, Bucks., HP12 4HL, U.K.

Purified herpes simplex virus thymidine kinase has been used to immunize mice for the production of monoclonal antibodies to the enzyme. Monoclonal antibodies were successfully produced against both herpes simplex virus type 1 and type 2 enzymes. These antibodies should prove useful for detecting the enzyme under a variety of experimental conditions. We also demonstrate that the antibodies can provide an alternative method for obtaining large amounts of purified thymidine kinase.

Keywords: HSV, monoclonal antibodies, thymidine kinase

Received 30 April 1984; accepted 24 May 1984.