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Antigenic Sites on the ERA Rabies Virus Nucleoprotein and Non-structural Protein

¹ Institut Pasteur, 25 rue du Docteur Roux, Paris 75724, France
and² The Wistar Institute of Anatomy and Biology, 36th Street at Spruce, Philadelphia, Pennsylvania 19104, U.S.A.

Thirty-one monoclonal antibodies, specific for either the nucleoprotein (N) or the non-structural protein (NS; nucleocapsid-associated protein) of the nucleocapsid of the ERA strain of rabies virus, were used to investigate the topography of antigenic sites on the nucleocapsid complex. Based on the results of a competitive enzyme immunoabsorbent assay using these antibodies, five spatially distinct antigenic sites were defined: three on the N protein (groups N I, N II and N III) and two on the NS protein (groups NS I and NS II). Antigenic variations among various street and laboratory strains of rabies virus were analysed by indirect immunofluorescence assay with the monoclonal antibodies specific for the nucleocapsid. Some correlation between the natural nucleocapsid variation and the antigenic topographical map was observed.

Keywords: rabies virus, N, NS, competitive binding

Received 22 January 1985; accepted 5 July 1985.

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